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Language neurofeedback (LNF) is an established intervention for treating apraxia of speech (AOS), although it is unclear which method of LNF (e.g., the dual-task method vs. the continuous-feedback method) is superior. To address this, we conducted a systematic review of LNF studies for treating AOS in children and adults. We searched PubMed, PsycINFO, and Cochrane for studies published from the year 2000 to 2017 that used a randomized or quasi-randomized controlled trial design. Primary outcome was language measures (e.g., monosyllabic word repetition, sentence repetition, picture description, single word production) at the end of intervention. Secondary outcome measures included measures of non-verbal cognitive skills (e.g., mental flexibility, set-shifting), executive function, as well as linguistic and communicative outcomes (e.g., word accuracy, duration of utterance, percent of normal rate of speech). Two reviewers conducted the quality assessment and data extraction. We included 14 studies (n = 534), and all studies showed a significant improvement in language measures. The dual-task group had a better effect size than the continuous-feedback group, whereas the latter showed better effects for non-verbal cognitive skills. The findings indicate that LNF is a promising intervention for treating AOS. Overall, the results were positive, although they were heterogeneous. More methodologically rigorous studies with large sample sizes are needed to better understand the role of neurofeedback in treating AOS.A new method for the separation and determination of antiviral nucleosides in biological samples.
A new method is described for the separation of antiviral nucleosides from biological samples. The method has been developed for use with samples containing relatively small amounts of the antiviral nucleosides (1--10 micrograms). It involves the formation of a chromatographic mixture of nucleosides on a column containing an acidic resin (TLCsulphite cellulose) and quantification of ac619d1d87
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